CompletedNot Applicable

Pretreatment With Dienogest in Women With Endometriosis Undergoing in Vitro-fertilization After a Previous Failed Cycle

Italy140 participantsStarted 2020-01-01

Plain-language summary

It is generally assumed that the major causes of in vitro fertilization (IVF) failure in women with endometriosis are diminished ovarian reserve, impaired endometrial receptivity and low quality of embryos. The use of prolonged courses of hormone therapy may play an important role in the strategy of overcoming endometriosis-related infertility. The aim of this study was to evaluate the use of dienogest (DNG) before an IVF cycle in women with endometriosis undergone a previous IVF failed cycle

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * diagnosis of endometriosis at magnetic resonance imaging or transvaginal ultrasonography; * one failed previous IVF cycle (including failure of frozen embryo transfer); * basal FSH \< 14.0 IU/L; * antimullerian hormone (AMH) blood level \>= 0.5 g/mL; * normal thyroid-stimulating hormone and prolactin. Exclusion Criteria: * history of surgery for endometriosis; * history of uterine or adnexal surgery; * use of hormonal therapies for the treatment of endometriosis related pain within 6 months before IVF; * adenomyosis (magnetic resonance imaging or transvaginal ultrasonography); * hydrosalpinx; * submucosal fibroids; * body mass index (BMI) ≥ 30 kg/m2; * severe male factor infertility (\< 5 million total motile sperm count).

What they're measuring

Clinical pregnancy rate

Timeframe: 8 weeks

Live birth rate after reaching 24 week's gestation

Timeframe: 24 weeks

Trial details

NCT IDNCT04306276

SponsorOspedale Policlinico San Martino

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-03-01

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