CompletedNot Applicable

Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers

Thailand28 participantsStarted 2018-04-06

Plain-language summary

The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.

Who can participate

Age range

35 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * non-CHD or CHD (at least 50% diameter stenosis in at least one coronary artery and clinically stable with absence of any potentially confounding inflammatory conditions for at least 6 months) * had at least 14 natural teeth excluding third molars Exclusion Criteria: * received anticoagulant drugs * had chronic conditions (e.g. diabetes mellitus, rheumatoid arthritis, malignancy, autoimmune disease) or acute conditions (e.g. trauma, surgery) or medications known to affect systemic inflammatory markers (e.g. antibiotics, immunosuppressive, contraceptives) within 3 months * pregnancy or lactation * presence or history of other infections * periodontal treatment within 6 months * tooth extractions within 2 months prior to the study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

change in fibrinogen level between baseline and 3 months after non-surgical periodontal treatment

Timeframe: 3 months after non-surgical periodontal treatment

change in activator inhibitor 1 between baseline and 3 months after non-surgical periodontal treatment

Timeframe: 3 months after non-surgical periodontal treatment

change in C-reactive protein between baseline and 3 months after non-surgical periodontal treatment

Timeframe: 3 months after non-surgical periodontal treatment

change in fibrinogen level between baseline and 6 months after non-surgical periodontal treatment

Timeframe: 6 months after non-surgical periodontal treatment

change in activator inhibitor 1 between baseline and 6 months after non-surgical periodontal treatment

Timeframe: 6 months after non-surgical periodontal treatment

change in C-reactive protein between baseline and 6 months after non-surgical periodontal treatment

Timeframe: 6 months after non-surgical periodontal treatment

Trial details

NCT IDNCT04305171

SponsorMahidol University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-01-31

View on ClinicalTrials.gov More Coronary Heart Disease trials