UnknownNot Applicable

Defecation Function and Quality of Life in the Patients Treated With Surgery for Slow Transit Constipation

China100 participantsStarted 2019-01-01

Plain-language summary

Although surgical options for slow transit constipation (STC) have been proven to be a definite treatment, improvements in the associated defecation function and quality of life are rarely studied. This study aims to investigate the effectiveness of total or subtotal colectomy, with respect to short- and long-term defecation function and overall quality of life in 5-year regular follow-up.

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. The clinical manifestations all met the Roman IV standard for the diagnosis of functional constipation.
. Patients with severe constipation symptoms were unable to defecate naturally and need laxatives to assist defecation or still unable to defecate.
. Colonic transport tests showed that the opaque X-ray markers remained more than 20% after 72 hours.
. All conservative treatment for more than 1 year failed.
. Patients had a strong desire for surgery, and no other contraindications to surgery.

Exclusion criteria

. Megacolon was detected with barium enema examination.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The number of bowel movements

Timeframe: from the pre-operation to the five years following surgery

The scales of Wexner Constipation

Timeframe: from the pre-operation to the five years following surgery

The scales of Wexner Incontinence

Timeframe: from the pre-operation to the five years following surgery

The incidence of abdominal pain

Timeframe: from the pre-operation to the five years following surgery

The incidence of bloating

Timeframe: from the pre-operation to the five years following surgery

The incidence of diarrhea

Timeframe: from the pre-operation to the five years following surgery

The incidence of straining

Timeframe: from the pre-operation to the five years following surgery

Trial details

NCT IDNCT04304183

SponsorThird Military Medical University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-12-31

Contact for this trial

Yue Tian, MD

18523159554 ty11860602@163.com

View on ClinicalTrials.gov More Defecation Function trials

Plain-language summary

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. The clinical manifestations all met the Roman IV standard for the diagnosis of functional constipation.
. Patients with severe constipation symptoms were unable to defecate naturally and need laxatives to assist defecation or still unable to defecate.
. Colonic transport tests showed that the opaque X-ray markers remained more than 20% after 72 hours.
. All conservative treatment for more than 1 year failed.
. Patients had a strong desire for surgery, and no other contraindications to surgery.

Exclusion criteria

. Megacolon was detected with barium enema examination.

What they're measuring

The number of bowel movements

Timeframe: from the pre-operation to the five years following surgery

The scales of Wexner Constipation

Timeframe: from the pre-operation to the five years following surgery

The scales of Wexner Incontinence

Timeframe: from the pre-operation to the five years following surgery

The incidence of abdominal pain

Timeframe: from the pre-operation to the five years following surgery

The incidence of bloating

Timeframe: from the pre-operation to the five years following surgery

The incidence of diarrhea

Timeframe: from the pre-operation to the five years following surgery

The incidence of straining

Timeframe: from the pre-operation to the five years following surgery