CompletedNot Applicable

The Relation Between Quadriceps Muscle Layer Thickness and Nitrogen Balance for Nutrition Monitoring

Egypt186 participantsStarted 2020-03-15

Plain-language summary

Loss of muscle mass is a major cause of intensive care unit-acquired weakness (ICU-AW) and is associated with delayed weaning; prolonged ICU and hospital stay and is an independent predictor of one year mortality. Theoretically, the best strategy to minimize muscle loss during ICU stay, is delivering an appropriate nutritional support. Studying the correlation between the sequential assessments of quadriceps femoris muscle layer thickness (QMLT) by the aid of Ultrasound in addition to the traditional method (NB) for assessment of nutritional status may be helpful to predict outcome and mortality.

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Anticipated to be mechanically ventilated to \>48hour and expected to Stay in ICU \> 4 days. * No contraindication to early enteral nutrition. * Enteral feeding in the first 24 hours after admission, with a minimum protein contribution of 1 gm / kg / day. * We recruited only well nourished, previously healthy patients with no past history of nutritional problems. Exclusion Criteria: * Patients with preexisting neuromuscular pathology, lower limb amputation, skeletal fractures or immobilization in the previous 2years. * Patients with relevant Co-morbidities (renal, liver or heart disease or COPD), previous immune abnormalities including those receiving corticosteroids, and those with past or recent history of cancer. * Patients with anuria owing to the difficulty in evaluating excreted urea nitrogen * Whose ultrasound data will be missing or incomplete * Pregnancy * Patients who will not reach the goal in enteral protein intake for any reason (gastrointestinal intolerance, contraindication to enteral feeding or repeated interruptions of enteral feeding due to multiple surgical procedures) or those who start parenteral nutrition.

What they're measuring

correlation between Nitrogen Balance and quadriceps muscle layer thickness (QMLT)

Timeframe: 10 days

Trial details

NCT IDNCT04303650

SponsorZagazig University

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2023-10-30