CompletedPhase 4

24 Vs 48 Hours of Cefazolin or Cefuroxime as Prophylaxis

Saudi Arabia568 participantsStarted 2018-02-06

Plain-language summary

A randomized control trial studying the effect of prophylactic antibiotics to reduce surgical site infections following cardiac surgery in adults using 1st generation cephalosporin (Cefazolin) or 2nd generation cephalosporin (Cefuroxime).

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Ability to provide informed consent * Planned to undergo a cardiac surgical procedure Exclusion Criteria: * Patients on antibiotics on the day of surgery or those who received any within 7 days for any reason * Patients taken to operating room as salvage * Patients who are allergic to either cefuroxime or cefazolin * Patients for LVAD or ECMO * Patients who are known MRSA carriers * Patients receiving steroid therapy

What they're measuring

surgical site infection rate is less with Cefuroxime than Cefazolin

Timeframe: within 3 months from date of surgery

surgical site infection rate is less with 48 hours rather than 24 hours

Timeframe: within 3 months from date of surgery

Trial details

NCT IDNCT04303390

SponsorSaud Al Babtain Cardiac Center

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2022-05-31

View on ClinicalTrials.gov More Surgical Site Infection trials