CompletedNot Applicable

Probiotic-Muscle Study

Ireland12 participantsStarted 2019-11-25

Plain-language summary

This study will examine the effect of probiotic supplementation (Bacillus coagulans) on muscle protein synthesis in older adults in response to a plant-based diet. The investigators hypothesize that probiotic supplementation will enhance the digestibility of plant protein, therefore increasing the proportion of ingested amino acids that appear in systemic circulation and enhancing rates of muscle protein synthesis.

Who can participate

Age range65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age: ≥65 y * Sex: males and female * Body mass index (BMI) between 20-35 kg/m2 * Non-smokers * Generally healthy according to responses to a standard health screening questionnaire Exclusion Criteria: * Cancer (malignancy in the past 5 years) * CVD * Chronic kidney disease * Liver failure * Diabetes or pre-diabetes * Conditions that will affect the ability to consume, digest and/or absorb the study supplement (i.e. gastrointestinal disease) * Smokers * Excess alcohol intake * Regular resistance training * Total walking incapacity * Musculoskeletal or neuromuscular impairments * Medications interfering with muscle metabolism * Ongoing probiotic supplementation * Antibiotic use in the previous 6 weeks * Significant body mass loss in the 1 month period prior to the study

What they're measuring

Myofibrillar protein synthesis

Timeframe: 6 months

Pattern of change in plasma total amino acid, essential amino acid and leucine concentrations

Timeframe: 6 months

Trial details

NCT IDNCT04297111

SponsorUniversity College Dublin

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-10-03

View on ClinicalTrials.gov More Old Age; Debility trials