CompletedNot Applicable

Brain Imaging Changes Following Proton Therapy for Pediatric Primary Central Nervous System and Base of Skull Tumors

United States36 participantsStarted 2019-01-21

Plain-language summary

This trial gathers information from patients with primary central nervous system or base of skull tumors that receive proton beam therapy and see if certain imaging techniques can help detect radiation-related changes over time. This study may help providers learn more about proton beam radiotherapy and how to improve the way it is delivered.

Who can participate

Age range21 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients must have histologically confirmed central nervous system of skull base tumors * Patient is going to undergo central nervous system (CNS) or base of skull proton beam therapy Exclusion Criteria: * Patients who have received prior therapeutic radiotherapy to the primary brain tumor site * Patients who are unable to maintain follow-up through the Phoenix Children's Hospital and Mayo Clinic Arizona

What they're measuring

White matter changes within the central nervous system (CNS) following proton beam therapy using magnetic resonance imaging (MRI) sequences

Timeframe: At 18 months

White matter changes within the CNS following proton beam therapy using diffusion tensor imaging (DTI) sequences

Timeframe: At 18 months

Relative biological effectiveness (RBE) predictions

Timeframe: Up to 18 months

Trial details

NCT IDNCT04296617

SponsorMayo Clinic

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-10-23

View on ClinicalTrials.gov More Malignant Central Nervous System Neoplasm trials