UnknownNot Applicable

Carnosine Supplementation on Quantity/Quality of Oral Salivae.

Italy60 participantsStarted 2022-09-01

Plain-language summary

The aim of this study is to elucidate the mutual relationship between salivae characteristics and oral microbiome and to compare them with common oral disease; furthermore, by using specific bioinformatic tools to analyse the data, the potentials of Carnosine in preventing/treating oral diseases and its mechanism of action will be addressed by using quantitative proteomics.

Who can participate

Age range18 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria for Oral Diseased subjects: * dental erosions (De) * caries (Ca) * périodontopathies (Pe) Exclusion Criteria for both: * allergies/intolerances to the consumption of Carnosine * taking other food supplements * any type of drug treatment (interview) * smoking * pregnancy/lactation * any systemic diseases such as cardiovascular and respiratory, diabetes mellitus, HIV infection, or inflammatory conditions causing non-plaque dependent OD.

What they're measuring

Effects on oral pH.

Timeframe: 7 days

Saliva Production unstimulated.

Timeframe: 7 days

Saliva Production stimulated.

Timeframe: 7 days

Trial details

NCT IDNCT04295525

SponsorUniversity of Milan

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12-01

Contact for this trial

Dino Re, MD

+39-0254176231 dino.re@unimi.it

View on ClinicalTrials.gov More Oral Diseases trials