CompletedNot Applicable

Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder

United States304 participantsStarted 2020-10-01

Plain-language summary

Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders. However, CBT is largely underutilized within the Department of Veterans Affairs due to the cost and burden of trainings necessary to deliver all of the related disorder-specific treatments (DSTs). Transdiagnostic Behavior Therapy (TBT), in contrast, is specifically designed to address numerous distinct disorders within a single protocol in Veterans with depressive/anxiety disorders, including posttraumatic stress disorder. The proposed research seeks to evaluate the efficacy of TBT by assessing psychiatric symptomatology and related impairment outcomes in Veterans with depressive/anxiety disorders via a randomized controlled trial of TBT and existing DSTs in Veterans with major depressive disorder, posttraumatic stress disorder, and panic disorder. Assessments will be completed at pre-, mid-, and post-treatment, and at 6-month follow-up. Process variables also will be investigated.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Participants must be Veterans * Participants must be clearly competent to provide informed consent for research participation * Participants must meet DSM-5 criteria for panic disorder, major depressive disorder, or posttraumatic stress disorder * Participants must be 18-80 years old Exclusion Criteria: * recent history (\< 2 months) of psychiatric hospitalization or a suicide attempt as documented in their medical record or reported during clinical interview * acute, severe illness or medical condition that likely will require hospitalization and/or otherwise interfere with study procedures as documented in their medical record (e.g., active chemotherapy/radiation treatment for cancer), * recent start of new psychiatric medication (\< 4 weeks) * diagnosis of moderate-to-severe traumatic brain injury in their medical record and/or endorsement of screener questionnaire * additional comorbid psychiatric diagnoses that were not listed as exclusion criteria are permitted as long as they are considered secondary to the principal diagnosis of MDD, PTSD, or PD/AG as determined by the diagnostic interview * ineligible Veterans will be referred for non-study-related treatments within mental health at the RHJ VAMC

What they're measuring

PTSD Checklist for DSM-5 (PCL-5)

Timeframe: change from baseline to week 6 to week 12 to 6-month followup

Patient Health Questionnaire - 9 (PHQ-9)

Timeframe: change from baseline to week 6 to week 12 to 6-month followup

Panic Disorder Severity Scale (PDSS)

Timeframe: change from baseline to week 6 to week 12 to 6-month followup

Trial details

NCT IDNCT04293341

SponsorVA Office of Research and Development

Sponsor typeFED

Study typeINTERVENTIONAL

Primary completion2025-01-01

Results submitted2025-10-23

View on ClinicalTrials.gov More Major Depressive Disorder trials

Plain-language summary

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

PTSD Checklist for DSM-5 (PCL-5)

Timeframe: change from baseline to week 6 to week 12 to 6-month followup

Patient Health Questionnaire - 9 (PHQ-9)

Timeframe: change from baseline to week 6 to week 12 to 6-month followup

Panic Disorder Severity Scale (PDSS)

Timeframe: change from baseline to week 6 to week 12 to 6-month followup