CompletedNot Applicable

Proteomics and Orthodontic Root Resorption

Iraq20 participantsStarted 2019-03-01

Plain-language summary

The majority of previous studies for early detection of Orthodontically Induced Inflammatory Root Resorption (OIIRR) were conducted to assess individual biomarkers which are representative of single biological pathway. To our Knowledge, no studies have been employed Gingival crevicular fluid (GCF) proteomic analysis to identify potential biomarkers for OIIRR. Therefore; the aim of this study is to use the advantage of testing a package of biomarkers via doing proteomic analysis of GCF which could help in making a more precise personalize diagnosis and treatments, thereby providing orthodontists additional information that cannot be deduced from clinical parameters.

Who can participate

Age range

18 Years – 32 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Orthodontic patients indicated for extraction of bilateral upper first premolars, * General healthy fit, * Good oral hygiene with periodontal health maintenance (Plaque Index and Gingival Index ≤1), * Lack of radiographic signs of idiopathic resorption, * Radiographically both experimental teeth have two roots with approximately equal length and shape, * The position of experimental teeth within the arch with no rotation. Exclusion Criteria: * Patients with impaction except impacted third molars for referral to do CBCT, * Smokers, * Patients on anti-inflammatory drugs at least three months before and during the study, * History of oral habit, * Previous orthodontic treatment, * History of dental trauma, * Previous dental treatment of the experimental teeth, * Patient with heavy occlusion, * Pathological lesion in the upper arch.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Biomarkers of Orthodontic Root Resorption

Timeframe: Baseline, 1hour, 1day, 7days, 14days, 21days and 28days

Trial details

NCT IDNCT04291443

SponsorUniversity of Baghdad

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-07-01

View on ClinicalTrials.gov More Root Resorption trials