CompletedNot Applicable

Proteomics and Orthodontic Root Resorption

Iraq20 participantsStarted 2019-03-01

Plain-language summary

The majority of previous studies for early detection of Orthodontically Induced Inflammatory Root Resorption (OIIRR) were conducted to assess individual biomarkers which are representative of single biological pathway. To our Knowledge, no studies have been employed Gingival crevicular fluid (GCF) proteomic analysis to identify potential biomarkers for OIIRR. Therefore; the aim of this study is to use the advantage of testing a package of biomarkers via doing proteomic analysis of GCF which could help in making a more precise personalize diagnosis and treatments, thereby providing orthodontists additional information that cannot be deduced from clinical parameters.

Who can participate

Age range18 Years – 32 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Orthodontic patients indicated for extraction of bilateral upper first premolars, * General healthy fit, * Good oral hygiene with periodontal health maintenance (Plaque Index and Gingival Index ≤1), * Lack of radiographic signs of idiopathic resorption, * Radiographically both experimental teeth have two roots with approximately equal length and shape, * The position of experimental teeth within the arch with no rotation. Exclusion Criteria: * Patients with impaction except impacted third molars for referral to do CBCT, * Smokers, * Patients on anti-inflammatory drugs at least three months before and during the study, * History of oral habit, * Previous orthodontic treatment, * History of dental trauma, * Previous dental treatment of the experimental teeth, * Patient with heavy occlusion, * Pathological lesion in the upper arch.

What they're measuring

Biomarkers of Orthodontic Root Resorption

Timeframe: Baseline, 1hour, 1day, 7days, 14days, 21days and 28days

Trial details

NCT IDNCT04291443

SponsorUniversity of Baghdad

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-07-01