UnknownPhase 4

Tranexamic Acid in Chinese Elderly Patients With Intertrochanteric Fracture RCT

Hong Kong120 participantsStarted 2018-05-23

Plain-language summary

Hip fracture posed a major challenge to the health care system, with the one-year mortality of hip fracture reported as being approximately 20%. Perioperative haemoglobin level was associated with functional level of the patient and even mortality. Different methods for administration of tranexamic acid had been described. It was well established that systemic administration of tranexamic acid could reduce perioperative blood loss and transfusion rate. Topical administration had been shown to decrease blood loss and transfusion rate. The objective of our study is to investigate the hypothesis that tranexamic acid will reduce blood loss and transfusion rate in elderly patients undergoing hip fracture surgery.

Who can participate

Age range

60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults over the age of 60 * Acute isolated intertrochanteric fracture and sub trochanteric fracture treated with short proximal femoral nailing Exclusion Criteria: * Use of any anticoagulant at the time of admission * Documented allergy to tranexamic acid * History of pulmonary embolism or deep vein thrombosis * Hepatic failure * Severe renal insufficiency * Active coronary artery disease in the past 12 months * History of cerebrovascular accident in the past 12 months * Presence of a drug-eluting stent * Active oncological diseases * Coagulopathy (international normalised ratio (INR)\>1.4) * Pathological fractures * Periprosthetic fractures * Operation \>2 days from admission

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Transfusion rate

Timeframe: Day 3 post operation

Blood loss

Timeframe: Day 3 post operation

Trial details

NCT IDNCT04290884

SponsorThe University of Hong Kong

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-02-14

View on ClinicalTrials.gov More Fracture of Femur trials