CompletedNot Applicable

Skeletal Fragility in Type 1 Diabetes: Glycemic Control and Bone Strength

United States86 participantsStarted 2020-01-01

Plain-language summary

The purpose of this research study is to find out how bones are affected in children and adolescents with type 1 diabetes (T1D) as compared to children and adolescents without type 1 diabetes.

Who can participate

Age range8 Years – 14 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria (T1D and Controls): \- Children within 2 years preceding the onset of the pubertal growth spurt Inclusion Criteria (T1D participants): \- documentation of β-cell autoimmunity and need for insulin replacement Exclusion Criteria: * Estimated glomerular filtration rate (eGFR)\< 60 ml/mim * 25(OH)D level \< 20 ng/ml. * Celiac disease * Autoimmune thyroid disease * Addison's disease * History of pathological fractures \-- Disorders associated with altered skeletal structure or function * Bone active drugs in past year * Diabetes of other or unclear etiology

What they're measuring

Change in microarchitecture by HR-pQCT

Timeframe: Two Years

Change in bone mineral density by Dual X-ray Absorptometry (DXA)

Timeframe: Two Years

Trial details

NCT IDNCT04289727

SponsorColumbia University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-09-08

View on ClinicalTrials.gov More Type1diabetes trials