Memory Retrieval and Encoding Investigated by Neural Stimulation (NCT04286776) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Memory Retrieval and Encoding Investigated by Neural Stimulation
United States800 participantsStarted 2014-10-12
Plain-language summary
The purpose of this research is to understand biomarkers of human memory through correlational analyses and to use focal electrical stimulation as a causal manipulation to understand how biomarkers of memory relate to other brain states and behavioral measures.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Expected to undergo intracranial implantation and postoperative electroencephalographic monitoring as part of a standard clinical procedure for the treatment of pharmacologically resistant epilepsy
. Age 18 or older
Exclusion criteria
. Any physical or cognitive disability or illness that would limit their ability to perform cognitive tasks
. Any medical condition that would, in the investigator's opinion, limit the subject's participation in the study.
. Unable or unwilling to provide informed consent
. MRI contraindications
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
To use direct electrical stimulation to disentangle causal versus correlative biomarkers of verbal and spatial episodic memory
Timeframe: Up to 4 weeks (typical duration of hospital stay)
2
To develop and test models of human brain dynamics in the presence of electrical stimulation
Timeframe: Up to 4 weeks (typical duration of hospital stay)
3
To assess how reactivation of prior memories shapes subsequent recall and memory organization, including memory for the content, context and value of experiences.
Timeframe: Up to 4 weeks (typical duration of hospital stay)
4
To determine whether state-dependent stimulation can separately be used to modulate encoding and retrieval processes
Timeframe: Up to 4 weeks (typical duration of hospital stay)
5
To determine whether stimulation is more effective at modulating memory when targeted to regions with specific connectivity profiles to the medial temporal lobe
Timeframe: Up to 4 weeks (typical duration of hospital stay)
6
To determine how simultaneous stimulation at multiple target sites can be optimized to modulate memory