CompletedNot Applicable

Prone Position and Renal Resistive Index

France20 participantsStarted 2020-06-30

Plain-language summary

Patients suffering from Acute Respiratory Distress Syndrome (ARDS) with a prone position (PP) indication will benefit from measurements of renal resistive index, intra-abdominal pressure (IAP), urinary oxygen tension (uPO2) and ventilatory mechanics in supine position (baseline IAP), after 2 hours in PP at the current IAP value, thirty minutes after patients' abdomen suspension in order to resume baseline IAP and after patients' are turned back to supine position.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ARDS patients according to Berlin criteria, intubated, mechanically ventilated * with PaO₂/FiO₂ \< 150 mmHg, * neuromuscular blockade * with an indication of PP done by the physician in charge * possibility to differ PP for one hour * patients should be hemodynamically stable since at least 4 hours Exclusion Criteria: * Pregnant or breast-feeding women * legal protection, no social security affiliation * PP contra-indication * nasogastric tube contra-indication * extra corporeal membrane oxygenation * acute kidney injury at inclusion according to K-DIO criteria, chronic kidney disease defined as an estimated glomerualr filtration rate less than 30 ml/min/1.73m², kidney transplantation, renal artery stenosis, solitary kidney, albuminuria \> 1.25 mg/ml * cardiac arrhythmia * obesity * advanced cirrhosis

What they're measuring

change in renal resistive index (RRI)

Timeframe: At inclusion (in supine position), two hours after prone positioning, 30-minutes after the abdomen suspension maneuver

Trial details

NCT IDNCT04286490

SponsorUniversity Hospital, Grenoble

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-06-30