CompletedNot Applicable

Mitomycin-C Injection Therapy in Refractory Esophageal Stricture

South Korea16 participantsStarted 2013-10-01

Plain-language summary

Intralesional Mitomycin-C (MMC) injection has recently been introduced to resolve refractory benign esophageal stricture mostly in children. The investigators aimed to evaluate the clinical efficacy of endoscopic postdilation intralesional injection of MMC in adults with refractory benign esophageal stricture.

Who can participate

Age range

29 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * aged more than 29 year and less than 75 year * refractory benign esophageal stricture who had the symptoms of dysphagia score suggested by Mellow et al greater than 3 (0: able to eat a normal diet, 1: able to eat some solid food, 2: able to eat some semi-solids only, 3: able to swallow liquids only, 4: complete dysphagia) Exclusion Criteria: Patients who have at least one of following conditions were excluded from our study * malignant esophageal stricture * multiple sites of esophageal stricture * pregnant or breast feeding status * clinical deterioration not tolerated to endoscopic procedures * esophageal motility disorders * esophageal leakage or fistula * hypersensitivity to mitomycin C * bleeding tendency due to thrombocytopenia or clotting disorders

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Initial clinical success of mitomycin C injection therapy

Timeframe: 12 months after mitomycin C injection

Overall clinical success of mitomycin C injection therapy

Timeframe: 12 months after mitomycin C injection

Trial details

NCT IDNCT04284826

SponsorAjou University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-08-31

View on ClinicalTrials.gov More Esophageal Stricture trials