Efficacy of Platelet- and Extracellular Vesicle-rich Plasma in Chronic Postsurgical Temporal Bone Inflammations

Inclusion Criteria: * chronic otitis media, defined as a presence of at least 1 of the following: visible ear discharge, indirect signs of ear discharge (e.g. on a pillow, clothes), ear itching, the sensation of ear fullness, clinical signs of acute exacerbation of chronic otitis media during an otomicroscopic examination. * non-cholesteatomatous chronic otitis media despite prior standard conservative treatment * non-cholesteatomatous chronic otitis media despite prior surgical treatment Exclusion Criteria: * the presence or suspicion of cholesteatoma * infection of venepuncture site * pregnancy * breastfeeding * long-term treatment with antimicrobial drugs * long-term treatment with immunosuppressant drugs * the presence of systemic infectious disease * the presence of an autoimmune disease * the presence of cancer * receiving other types of experimental treatment for chronic otitis media