Fecal Microbiota Transplantation for the Treatment of Severe Acute Gut Graft-Versus-Host Disease

Inclusion Criteria: * Subjects who received an allogenic hematopoietic stem cell transplantation (HSCT) * Acute GvHD defined as experiencing GvHD symptoms starting prior to day +100 after HSCT * Gut GvHD defined as subjects experiencing GvHD symptoms consistent with stage 3 or stage 4 by Center for International Blood and Marrow Transplant Research (CIBMTR) staging: * Stage 3 acute gut GvHD subjects having 1500-1999 mL stool per day * Stage 4 subjects having greater than 2 liters of stool per day and/or severe abdominal cramping, bleeding or ileus * Steroid-refractory acute gut GVHD defined as progression of symptoms after 3 days of systemic steroids (\> 1 mg/kg/day methylprednisolone) or steroid-resistant acute gut GvHD defined stable symptoms after 5 days of systemic steroids (\> 1 mg/kg/day methylprednisolone) * Able to swallow capsules without aspiration or dysphagia * Ability to understand the written informed consent and the willingness to sign the consent and accept the risk of receiving unrelated donor stool Exclusion Criteria: * Absolute neutrophil count \< 500 cells/uL * Presence of recurrent Clostridium difficile infection * Presence of ileus or toxic megacolon * History of multi-drug resistant stool pathogen * History of inflammatory bowel disease (i.e Crohn's disease or ulcerative colitis) * Uncontrolled and active systemic infection from bacteria, virus or fungus * Human immunodeficiency virus (HIV)-positive subjects * Quantifiable cytomegalovirus (CMV) …