The hypothesis of the study is that ovaries of women with a history of poor response to ovulation induction may benefit from exposure to growth factors known to be present in Platelet Rich Plasma (PRP). Since even ovaries from women with poor response still contain primordial follicles (which, however, no longer undergo recruitment), it is hoped that PRP injections into ovaries will activate follicular recruitment pathways and, subsequently, result in follicle growth. Should such growth be observed, follicles will be supported with routine daily gonadotropin stimulation until hCG trigger.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Emergence of new ovarian follicles with evidence of estradiol production
Timeframe: Change from baseline to 12 weeks