UnknownNot Applicable

Incidence of Neurogenic Paraosteoarthropathies in a Population of Brain Traumatized and Spinal Cord Injured Patients and Specific Markers of Early NPOA Development"

118 participantsStarted 2023-09-15

Plain-language summary

Neurogenic paraosteoarthropathies are peri-articular bone formations that may occur as a result of central neurological injury. Their occurrence limits reeducation and recovery capacities. Neurogenic paraosteoarthropathies sometimes cause complications (pain, joint stiffness, vascular and nerve compression, pressure sores) in patients already suffering from severe neurological sequelae affecting functional prognosis. A lot of clinical research work has been carried out within Dr Salga team. Subsequently, a collaboration was born with fundamental research teams (Pr Levesque, Pr Le Bousse Kerdilès, Pr Banzet, Pr Genêt) allowing translational work between humans and animals. The clinical application of recent research findings now makes it possible to launch the very first prospective study on neurogenic paraosteoarthropathies.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male or Female \> 18 years old, * brain trauma with initial Glasgow score \< 8, * or brain trauma with an initial Glasgow score between 8 and 14 associated with an Injury Severity Score (ISS) \> 15 and surgery within 24 hours of admission or traumatic spinal cord injury with complete neurological impairment (initial para/tetraplegia), * Complete traumatic spinal cord injury. Accident less than 48 hours old * Informed consent signed by the patient or a family member Exclusion Criteria: * Age \< 18 years, * Hemorrhagic shock or blood transfusion greater than or equal to 4 red blood cells within 6 hours of the trauma (also include pre-hospital or first hospital red blood cells) * Follow-up impossible over one year, * Patient not living in the Paris region, * Pregnant or breastfeeding woman, * Patient under guardianship or curatorship, * No affiliation to a social security scheme or universal mutual fund.

What they're measuring

Incidence of Neurogenic Paraosteoarthropathies

Timeframe: 9 months

Trial details

NCT IDNCT04273347

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-11-15

Contact for this trial

Marjorie salga, MD

+33 1 47 10 70 82 marjorie.salga@aphp.fr