A Phase Ib/II Study of the Safety and Immunogenicity of the Candidate Rabies Vaccine ChAdOx2 RabG

Inclusion Criteria: * Adult groups: Healthy male or female adults aged 18-45 years at the time of enrolment with signed consent. * Adult groups (Female only participants): Must be non-pregnant (as demonstrated by a negative urine pregnancy test) and willing to use an effective form of contraception. Or if they agree to an extended period of follow-up of up to 5.5 years, use an effective form of contraception during the first year of enrolment in the study). * Paediatric groups: Healthy male or female young children aged 2-6 years at the time of enrolment with signed consent obtained from parents or guardians. * Paediatric groups: completion of the Expanded Programme on Immunisation (EPI) at least 6 months prior to study enrolment. * Planned long-term (at least 61 months from the date of the first vaccination) or permanent residence in Bagamoyo town. * Adults with a Body Mass Index (BMI) 18 to 35 Kg/m2; or young children with Z-score of weight-for-age within ±2SD. * Correctly answer all 10 questions on the protocol and study procedures understanding questionnaire within 2 attempts. Exclusion Criteria: * Clinically significant congenital abnormalities as judged by the PI or other delegated individual. * Clinically significant history of skin disorder, allergy, cardiovascular disease, respiratory disease, endocrine disorder, liver disease, renal disease, gastrointestinal disease and neurological illness which may significantly increase the risk to the volunteer because of par…