The Effects of Semaglutide on Taste, Tongue Tissue Transcriptome, Gastric Emptying and Central Neural Response in Women With PCOS and Obesity

Inclusion Criteria: * Informed written consent * Diagnosed with PCOS by Rotterdam criteria * BMI \> 30 kg/m2 * Age 18 years-menopause Exclusion Criteria: * Severe psychiatric disease including schizophrenia, paranoid psychosis, bipolar disorder or mental retardation * Current history of neurological disease including traumatic brain surgery * Current history of diagnosis of type I or type II diabetes or plasma haemoglobin A1c 6.5% at inclusion * Impaired hepatic function (liver transaminases\>3 times upper normal limit) * Impaired renal function (estimated glomerular filtration rate (eGFR)\< 50 ml/min * Impaired pancreatic function (any history of acute or chronic pancreatitis and/or amylase \>2 times upper limit) * Bleeding disorders * Women who are pregnant, breast feeding or have intention of becoming pregnant within the next 9 months * Women who are planning any operation within the next 6 months * History of medullary thyroid carcinoma (MTC) and/or family history with MTC and/or multiple endocrine neoplasia syndrome type 2 * Cardiac problems defined as decompensated heart failure (New York Herat Association functional class III or IV), unstable angina pectoris, and/or myocardial infarction within the last 12 months * Uncontrolled hypertension (systolic blood pressure \> 180 mmHg, diastolic blood pressure \> 110 mmHg * Receiving GLP-1 agonist within the last 12 months * Use of any weight-lowering pharmacotherapy within the preceding 3 months * Contraindication for MR s…