Stopped: As a busy MTF we were unable to retain a health care provider with the appropriate expertise to buy-in to this study once the initiating PI left military service.
Current treatment for acutely suicidal patients are limited to hospitalization, psychotherapy, electro-convulsant therapy, or a combination of the aforementioned. However, this has added to the national boarding problem. Long term pharmacologic treatment for suicidal behaviors and mood stabilization has been studied in specific populations. In these populations, the decreases in suicidal ideation results from stabilization of the underlying psychiatric illness. Ketamine is most commonly used as an anesthetic with analgesic properties. It has been used off-label for pain management, procedural sedation, status epilepticus, and treatment resistant depression. It has been safely administered intravenously and well tolerated for chronic Post Traumatic Stress Disorder. It increases norepinephrine, dopamine, and serotonin through adrenergic neuron stimulation and prevention of catecholamine uptake. There is a strong corollary between stress and the development of depression and suicidal behaviors. It is proposed that the use of low dose intravenous ketamine may have benefit on the suicidal ideation of patients presenting to the Emergency Department.
Age range
18 Years – 89 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Suicidal Severity - Clinical Efficacy
Timeframe: 4 hour+/1 after infusion completion (performed for placebo and drug arms)
Suicidal Severity - Clinical Efficacy
Timeframe: 24-36 hours after infusion completion (performed for placebo and drug arms)
Suicidal Severity - Efficacy at 1 Week
Timeframe: 1week+/-1 day after infusion completion (performed for placebo and drug arms)
Depression Symptoms - Clinical Efficacy
Timeframe: 4 hours +/-1 after infusion completion (Performed for placebo and drug arms)
Depression Symptoms - Clinical Efficacy
Timeframe: 24-46 hours after infusion completion (Performed for placebo and drug arms)
Depression Symptoms - Efficacy at 1 Week
Timeframe: 1 week +/-1 day after infusion completion, performed for placebo and drug arms