CompletedNot Applicable

Impact of Hypothalamic Gliosis on Appetite Regulation and Obesity Risk in Children

United States101 participantsStarted 2020-02-21

Plain-language summary

BEAM is a multi-site longitudinal cohort study of hypothalamic gliosis, central regulation of appetite and weight gain in children. Participants will be recruited from the community in the greater Seattle and greater Baltimore area. All participants will consent to enroll in the 24-month study during which they will complete 5 in-person study visits.

Who can participate

Age range9 Years – 11 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 9-11 y (at time of enrollment) * BMI ≥ 15th percentile for age and sex Exclusion Criteria: * Significant Health conditions (e.g., type 2 diabetes) * Documented cognitive disorder * History of major weight loss of 10lbs or more, not due to illness, over the past year * Eating disorder (e.g. anorexia, bulimia) * Current use of medications known to alter appetite, body weight or brain response including: Anti-epileptics; Glucocorticoids; Antipsychotics; Stimulants for ADHD * MRI contraindication (e.g. implanted metal, claustrophobia, inability to fit in MRI scanner) * Weight \>330 pounds (MRI limit) * Severe food allergies, vegetarian, or vegan, or unable to eat study foods * Currently in formal weight loss program

What they're measuring

Hypothalamic gliosis

Timeframe: 2 years

Habitual dietary intake

Timeframe: 2 years

Obesity

Timeframe: 2 years

Trial details

NCT IDNCT04260048

SponsorUniversity of Washington

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-03-28

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