CompletedNot Applicable

Prophylatic Effect Preoperative Antibiotics With Mechanical Bowel Preparation in SSIs: A Propensity Analysis

806 participantsStarted 2011-01-01

Plain-language summary

Surgical site infections (SSIs) are a major postoperative complication after colorectal surgery. Current study aims to evaluate prophylactic function of oral antibiotic intake (OA) in combination with mechanical bowel preparation (MBP) relative to MBP alone with respect to postoperative SSIs incidence. A retrospective analysis of eligible patients was to conducted using the databases of the Gastrointestinal Surgery Centre, Third Affiliated Hospital of Sun Yat-sen University from 2011 to 2017. Data pertaining to postoperative hospital stay length, expenses, SSIs incidence, anastomotic fistula incidence, and rates of other complications wloud be extracted and compared. A propensity analysis was conducted to minimize bias associated with demographic characteristics.

Who can participate

SexALL

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Inclusion criteria

✓. Patient underwent elective colorectal resection to treat a malignancy;
✓. Patient baseline characteristics and operative information were available;
✓. MBP (mechanical bowel preparation) was performed before surgery, with or without OA (oral antibiotics).

Exclusion criteria

✕. Emergency surgery;
✕. MBP was not conducted due to ileus or patient refusal;
✕. Enough data was not available;
✕. Colorectal resection was performed due to benign disease;
✕. The procedure was accompanied by other procedures that had the potential to contaminate the incision, such as cholecystectomy or appendectomy;
✕. Patients underwent neoadjuvant radiotherapy before surgery.

What they're measuring

SSIs incidence

Timeframe: up to 30 days postoperatively

Trial details

NCT IDNCT04258098

SponsorThird Affiliated Hospital, Sun Yat-Sen University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2017-12-31

View on ClinicalTrials.gov More Surgical Site Infection trials