Reinforced PTFE Meshes Versus Customized Titanium Meshes

Inclusion Criteria: Adult patients, over the age of 18, in good general health. * Patients with partial edentulism of the maxilla or mandible, with a 2mm minimum to a 12mm maximum vertical bone defect, which requires a three-dimensional bone regeneration intervention in order to have a fixed implant supported rehabilitation. * Obtaining informed consent for experimental treatment and processing the personal data. Exclusion Criteria: * Poor oral hygiene, * Untreated periodontal disease * Smoking habit\> 10 cigarettes / day; * Abuse of alcohol or drugs * Pregnancy * Patients with odontostomatological infections and / or systemic infections in progress; * Patient with uncontrolled diabetes mellitus or other metabolic diseases; * Patients with severe changes in liver and kidney function. * Patients with confirmed uncontrolled autoimmune disorders. * Patients subjected radiation therapy in the head or neck region in the last 5 years. * Patients undergoing immunosuppressive and / or immunocompromised therapy.