Autologous Platelet Concentrate (APC) in Intrabony Defects

Inclusion Criteria: * Systemically healthy males and females ≥25 years old * Willingness to read and sign a copy of the Informed Consent Form after reading the Patient Information Sheet, and after the nature of the study has been fully explained * Clinical evidence of periodontitis, with one interdental area of PPD ≥6mm, BOP, and attachment loss ≥6mm, with associated intrabony defect ≥3mm in any area of their mouth (excluding third molars and distal of second molars) * Full mouth bleeding and plaque scores (FMBS and FMPS) \<25%recorded within the previous 6 weeks * Non-surgical treatment completed within 6 months prior to assessment for eligibility Exclusion Criteria: * Medical history that includes diabetes type 1 or hepatic or renal disease, or other serious medical conditions or transmittable diseases (e.g. cardiovascular disease or AIDS). * Antibiotic or anti-inflammatory therapy during the month preceding the baseline exam. * In chronic treatment (\>2 weeks) with anticoagulants, corticosteroids or other medications that can severely impact on bone formation * History of alcohol or drug abuse. * Smoking ≥10 cigarettes a day * Self-reported pregnancy or lactation (this criterion is due to oral tissue changes related to pregnancy and nursing, which can affect interpretation of study results). * Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or investigational product …