UnknownPhase 4

Assessment of Inhibition of Biofilm Formation and Plaque Bacterial Count of Fluoride Varnish Containing Chlorhexidine and Cetylpyridinium Chloride Versus Conventional Fluoride Varnish

Egypt34 participantsStarted 2020-02-01

Plain-language summary

Two different Fluoride varnish systems(Fluoride varnish containing Chlorhexidine and Cetylpyridinium Chloride (CPC) and conventional fluoride) will be applied to high caries risk patients to assess their clinical effects on plaque accumulation and plaque bacterial count .

Who can participate

Age range

18 Years – 40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Patients with good general state of health. * No signs of periodontitis. * Patients had a recorded high bacterial count after caries risk assessment. * No antibiotic treatment within 1 month prior to the start of the trial. * No current medication with anti-inflammatory drugs. * No use of antiseptic mouth rinses. * Non-smokers. Exclusion Criteria: * Patients with disabilities, systemic disease or severe medical conditions. * Patients with severe or active periodontal disease. * Antibiotic treatment within 1 month prior to the start of the trial. * Current medication with anti-inflammatory drugs.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Plaque Retention

Timeframe: Patient will be evaluated at 2nd week of the study in the morning before teeth brushing.

Plaque Retention

Timeframe: Patient will be evaluated at 4th week of the study in the morning before teeth brushing.

Plaque Retention

Timeframe: Patient will be evaluated at 12th week of the study in the morning before teeth brushing.

Plaque Retention

Timeframe: Patient will be evaluated at 24th week of the study in the morning before teeth brushing.

Trial details

NCT IDNCT04254835

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-07-01

Contact for this trial

Hadeer H Mohamed

01015779373 hadeer.hesham91@gmail.com

View on ClinicalTrials.gov More High Caries Risk Patients trials

Who can participate

Age range

18 Years – 40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Plaque Retention

Timeframe: Patient will be evaluated at 2nd week of the study in the morning before teeth brushing.

Plaque Retention

Timeframe: Patient will be evaluated at 4th week of the study in the morning before teeth brushing.

Plaque Retention

Timeframe: Patient will be evaluated at 12th week of the study in the morning before teeth brushing.

Plaque Retention

Timeframe: Patient will be evaluated at 24th week of the study in the morning before teeth brushing.