CompletedNot Applicable

Antithyroidal Antibodies With or Without Subclinical Hypothyroidism During Pregnancy in Infertile Women

Switzerland96 participantsStarted 2018-02-01

Plain-language summary

One prospective observational study was carried out in 2009 aiming at identifying the fluctuations of the thyroid hormones in women with normal thyroid gland and in women with anti-TPO antibodies. Serum samples were collected periodically during and after pregnancy in previously infertile women. The samples were stored frozen at -80 °C. Now, the hormone measurements will be carried out.

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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Inclusion Criteria: * previous infertility with known thyroidal function (TSH, anti-TPO) Exclusion Criteria: * other endocrine pathology, such as Addison, diabetes mellitus * manifest thyroidal pathology, such as Graves disease * contraindication against pregnancy * after repeated miscarriage (3 or more) * heavy smokers (20 cig per day or more)

What they're measuring

Deviations from euthyroid function as given by serum levels of TSH (expressed in mIU/l) during pregnancy and after birth.

Timeframe: 12 months

Trial details

NCT IDNCT04249271

SponsorUniversity Hospital, Basel, Switzerland

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-12-31

View on ClinicalTrials.gov More Thyroid Gland Disease trials