Prehabilitation to Improve Cancer Surgery Outcomes in AYA Patients With Extremity Sarcomas

Inclusion Criteria: * ≥18 years and \<40 years of age at diagnosis * Fluent in English * Able to comply with study and follow-up procedures contained within the consent form * Pathologically or radiologically confirmed diagnosis of a soft-tissue or osteosarcoma of the upper or lower extremities * Soft-tissue or osteosarcoma must be considered operable * Patients of all weight bearing states will be eligible * Expected LOS ≥ 5 days as calculated by the validated American College of Surgeons Surgical Risk Calculator * \>14 days between time of randomization and time of expected surgery * Patient written, informed consent obtained according to ICH GCP guidelines and local regulations * Medical clearance to participate in the study from either the primary treating surgeon (JW, PF) or oncologist (AG) Exclusion Criteria: * Planned resection of bony pelvis or major lower extremity neurovascular structures * Significant comorbidity including any of the following: * Canadian Cardiovascular Society class III/IV coronary disease * New York Heart Association class III/IV congestive heart failure * Neurologic or musculoskeletal disorder prohibiting exercise * Major neuropsychiatric disorder * High-risk or presence of pathological fracture