CompletedNot Applicable

Postprandial Inflammation in Rheumatoid Arthritis

Sweden56 participantsStarted 2020-02-01

Plain-language summary

Patients with RA will be studied to see whether meals of different content will affect inflammation and metabolic variables in the postprandial state. Healthy controls will also be invited to examine potentially different responses to patients with RA.

Who can participate

Age range

20 Years – 70 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria for patients with RA: * Diagnosed with rheumatoid arthritis * BMI 18.5-30.0 kg/m2 * 2 years or more since diagnosis * No DMARD changes during the last 3 months Inclusion Criteria for healthy controls: * Absence of diagnosis of RA * BMI 18.5-30.0 kg/m2 * Self-assessed as healthy Exclusion Criteria: * Diagnosis of cancer, inflammatory bowel disease, celiac disease, diabetes * Allergy or intolerance to any of the foods in the study * Pregnancy or breastfeeding * Use of any blood lipid lowering medication, glucocorticoids or IL-6-inhibitor during the last 4 weeks prior to enrolment * Smoking * Hemoglobin \< 100 g/L

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Circulating interleukin 6

Timeframe: From baseline up to 5 hours postprandial

Circulating high sensitive C-reactive protein (CRP)

Timeframe: From baseline up to 5 hours postprandial

Circulating triacylglycerides

Timeframe: From baseline up to 5 hours postprandial

Gene expression analysis

Timeframe: From baseline up to 5 hours postprandial

Serum metabolomics

Timeframe: From baseline up to 5 hours postprandial

Urine metabolomics

Timeframe: From baseline up to 5 hours postprandial

Trial details

NCT IDNCT04247009

SponsorGöteborg University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-11-17

View on ClinicalTrials.gov More Arthritis, Rheumatoid trials

Who can participate

Age range

20 Years – 70 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Circulating interleukin 6

Timeframe: From baseline up to 5 hours postprandial

Circulating high sensitive C-reactive protein (CRP)

Timeframe: From baseline up to 5 hours postprandial

Circulating triacylglycerides

Timeframe: From baseline up to 5 hours postprandial

Gene expression analysis

Timeframe: From baseline up to 5 hours postprandial

Serum metabolomics

Timeframe: From baseline up to 5 hours postprandial

Urine metabolomics

Timeframe: From baseline up to 5 hours postprandial