RecruitingNot Applicable

Induced Membrane Properties in Children and Adults

France50 participantsStarted 2019-05-23

Plain-language summary

Bone reconstruction in critical sized defect (CSD) remains a real challenge in orthopedic surgery in children and adults. The Masquelet technique is an innovative therapeutic technique, which offers a bone reconstruction in two steps, by the formation of an induced membrane (IM) around a polymethylmethacrylate (PMMA) spacer placed into the bone defect. After, PMMA removal, the cavity is filled with corticocancellous graft allowing bone healing. Up to date, all angiogenesis and osteogenic properties of IM remain unknown. The purpose of this study is to characterize angiogenesis and osteogenic properties of IM in children and adults.

Who can participate

Age range9 Months – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All patients treated at CHU Amiens-Picardie for bone critical sized defect treated using the induced membrane reconstruction technique. * patients from 9 months to 60 years old Exclusion Criteria: * Patients managed by another reconstruction technique for critical sized defect * Patients under guardianship, curators or deprived of liberty. * Pregnant and nursing women. * Patients who refused to participate in the study and to sign informed consent.

What they're measuring

Measure of the BMP2 concentration of the induced membrane by immunodetection

Timeframe: one year (one year from day of surgery)

Trial details

NCT IDNCT04246944

SponsorCentre Hospitalier Universitaire, Amiens

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-01

Contact for this trial

Céline Klein, MD

(33)322087571 klein.celine@chu-amiens.fr

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