Evaluation of the Effect of Sevoflurane and Propofol Hypotensive Anesthesia on Blood Antioxidant … (NCT04246567) | Clinical Trial Compass
SuspendedNot Applicable
Evaluation of the Effect of Sevoflurane and Propofol Hypotensive Anesthesia on Blood Antioxidant Levels and HIF 1 Levels
Stopped: Ethics approval is expected from the pharmaceutical institution for the study which has received the local ethics committee approval.
Turkey (Türkiye)60 participantsStarted 2019-03-01
Plain-language summary
The aim of this study to evaluate the patients who underwent controlled hypotensive anesthesia under standardized depth of anesthesia with total intravenous anesthesia or inhalation anesthesia; preoperative and 30. ,60. ,120. second of intraoperative period blood HIF 1a, TAS, TOS measurement and to investigate tissue hypoxia secondary to hypotensive anesthesia and the changes of the mediators at the tissue level and which hypotensive anesthesia technique is related.
Who can participate
Age range
18 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 18-55 years old
* ASA Physical Status Classification System 1
* Undergoing to Elective rhinoplasty
Exclusion Criteria:
* Patients have any autoimmune disease
* Smoking of patients
* Development of any allergic reaction during the procedure
* Failure to collect blood to be examined at the appropriate time
* Body mass index is less than 19 or greater than 30
Termination criteria
* Development of severe hypotension and bradycardia during measurements
* Development of severe drug allergy during follow-up
* In the event of any complications related to the surgical procedure
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Evaluation of the relationship between hypotensive anesthesia technique and tissue hypoxia by HIF1a
Timeframe: Change from Baseline HIF 1a 30th minute (t1), 1st hour (t2) and 2st hour (t3)
2
Evaluation of the relationship between hypotensive anesthesia technique and tissue hypoxia by the concentration of TAS
Timeframe: Change from Baseline TAS levels at 30th minute (t1), 1st hour (t2) and 2st hour (t3)
3
Evaluation of the relationship between hypotensive anesthesia technique and tissue hypoxia by the concentration of TOS
Timeframe: Change from Baseline TOS levels at 30th minute (t1), 1st hour (t2) and 2st hour (t3)