SuspendedNot Applicable

Evaluation of the Effect of Sevoflurane and Propofol Hypotensive Anesthesia on Blood Antioxidant Levels and HIF 1 Levels

Stopped: Ethics approval is expected from the pharmaceutical institution for the study which has received the local ethics committee approval.

Turkey (Türkiye)60 participantsStarted 2019-03-01

Plain-language summary

The aim of this study to evaluate the patients who underwent controlled hypotensive anesthesia under standardized depth of anesthesia with total intravenous anesthesia or inhalation anesthesia; preoperative and 30. ,60. ,120. second of intraoperative period blood HIF 1a, TAS, TOS measurement and to investigate tissue hypoxia secondary to hypotensive anesthesia and the changes of the mediators at the tissue level and which hypotensive anesthesia technique is related.

Who can participate

Age range18 Years – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18-55 years old * ASA Physical Status Classification System 1 * Undergoing to Elective rhinoplasty Exclusion Criteria: * Patients have any autoimmune disease * Smoking of patients * Development of any allergic reaction during the procedure * Failure to collect blood to be examined at the appropriate time * Body mass index is less than 19 or greater than 30 Termination criteria * Development of severe hypotension and bradycardia during measurements * Development of severe drug allergy during follow-up * In the event of any complications related to the surgical procedure

What they're measuring

Evaluation of the relationship between hypotensive anesthesia technique and tissue hypoxia by HIF1a

Timeframe: Change from Baseline HIF 1a 30th minute (t1), 1st hour (t2) and 2st hour (t3)

Evaluation of the relationship between hypotensive anesthesia technique and tissue hypoxia by the concentration of TAS

Timeframe: Change from Baseline TAS levels at 30th minute (t1), 1st hour (t2) and 2st hour (t3)

Evaluation of the relationship between hypotensive anesthesia technique and tissue hypoxia by the concentration of TOS

Timeframe: Change from Baseline TOS levels at 30th minute (t1), 1st hour (t2) and 2st hour (t3)

Trial details

NCT IDNCT04246567

SponsorBezmialem Vakif University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-09-01

View on ClinicalTrials.gov More Hypoxemia During Surgery trials