Since abnormal keratinocyte (KC) proliferation and differentiation as well as defective E cadherin expression were reported in vitiligo lesions, the investigators set to study the potential efficacy of combining Retinoids, which are known to improve KC proliferation and differentiation and increase the expression of adhesion molecules, with narrowband UVB in the treatment of vitiligo.
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Determining whether addition of acitretin is beneficial for vitiligo patients or not using Vitiligo Area Scoring Index
Timeframe: 4-5 months
Determining whether addition of acitretin is beneficial for vitiligo patients or not using Vitiligo Disease Activity Score.
Timeframe: 4-5 months