Combined Effect of Acitretin and Narrow Band Ultraviolet B on Vitiligo Repigmentation (NCT04245319) | Clinical Trial Compass
UnknownNot Applicable
Combined Effect of Acitretin and Narrow Band Ultraviolet B on Vitiligo Repigmentation
Egypt20 participantsStarted 2020-01-01
Plain-language summary
Since abnormal keratinocyte (KC) proliferation and differentiation as well as defective E cadherin expression were reported in vitiligo lesions, the investigators set to study the potential efficacy of combining Retinoids, which are known to improve KC proliferation and differentiation and increase the expression of adhesion molecules, with narrowband UVB in the treatment of vitiligo.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with generalized non-segmental vitiligo (25%-75%)
* Males, postmenopausal females and premenopausal females not planning to get pregnant during the period of treatment and after 2 years from the end of treatment.
* Age more than 18 years.
Exclusion Criteria:
* Children ˂ 18 years old
* Pregnant females
* Premenopausal females planning to get pregnant within the period of treatment or within 2 years after.
* Patients receiving treatment for vitiligo within the past 2 months.
* Patients with abnormal liver profile
* Patients with abnormal lipid profile
* Patients with associated photosensitive disorders
* Patients having associated skin diseases other than vitiligo
* Cataract and aphakia
* High cumulative dose from previous sessions of narrowband ˃ 200-300 session
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Determining whether addition of acitretin is beneficial for vitiligo patients or not using Vitiligo Area Scoring Index
Timeframe: 4-5 months
2
Determining whether addition of acitretin is beneficial for vitiligo patients or not using Vitiligo Disease Activity Score.