Comparing Two Methods to Follow Patients With Pancreatic Cysts

* Patient must be ≥ 50 years and ≤ 75 years of age. * Patient must not have acute pancreatitis or a history of chronic pancreatitis. * Patient must have received a CT, MRI, or EUS within 6 months prior to randomization that revealed one or more ≥ 1 cm pancreatic cyst (s). * Patients of childbearing potential must not be known to be pregnant. * Patient must not have a prior diagnosis of pancreatic malignancy of any type. * Patient must not have a history of pancreatic resection. * Patients with only pancreatic lesions without malignant risk (pancreatic pseudocyst or classic serous cystic lesion) are not eligible. * Patient must not have a family history of pancreatic adenocarcinoma in one or more first degree relatives(biological parents, full siblings or children). * Patient must not have pancreatic cyst morphology that would prompt immediate surgical consideration (enhancing mural nodule, solid component in cyst, pancreatic duct ≥10mm, cyst causing obstructive jaundice). * Patient must not have a comorbid illness that precludes pancreatic cyst resection. * Patient must not be participating in any form of pancreatic cyst surveillance.