CompletedNot Applicable

Effects of Intraovarian Platelet Rich Plasma in Women With Poor Ovarian Response and Premature Ovarian Insufficiency

Turkey (Türkiye)500 participantsStarted 2020-01-27

Plain-language summary

Reproductive age women diagnosed with poor ovarian response (POR) based on Poseidon criteria and premature ovarian insufficiency (POI) based on ESHRE criteria and with a history of at least one prior failed IVF cycle will be recruited for the study. Antral follicle count (AFC), serum anti-mullerian hormone (AMH), and early follicular phase serum follicle stimulating hormone (FSH) levels will determined at baseline. Autologous blood obtained from peripheral vein will be used to prepare PRP following standard protocols and will be injected to at least one ovary. Ovarian reserve parameters and IVF outcomes will be determined.

Who can participate

Age range20 Years – 48 Years

SexFEMALE

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Inclusion Criteria: * Patients with a history of \>1 year infertility duration with at least one ovary, who fulfilled the ESHRE criteria, * Patients diagnosed with POR based on Poseidon criteria and with a history of at least one prior failed IVF cycle Exclusion Criteria: * Presence of pregnancy, * previous diagnosis of any malignancy, * ovarian insufficiency secondary to sex chromosome etiology, * prior major lower abdominal surgery resulting in pelvic adhesions, * anticoagulant use for which plasma infusion is contraindicated, * current or previous (Immunoglobulin A (IgA) deficiency

What they're measuring

Ovarian reserve parameters

Timeframe: 6 months

Trial details

NCT IDNCT04237909

SponsorAcibadem University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-10-31

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