The purpose of this study is to assess the impact of suvorexant on established measures of smoking relapse risk (craving,withdrawal, stress reactivity, latency to self-administration) and to validate the somnolent effect of suvorexant on sleep metrics in a sample of individuals with tobacco use disorder
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Stress as Assessed by a Visual Analog Scale (VAS) for Stress
Timeframe: Day 1
Stress as Assessed by a Visual Analog Scale (VAS) for Stress
Timeframe: Day 8
Change in Stress Reactivity as Assessed by Heart Rate During the Cold Pressor Test (CPT)
Timeframe: Day 1 baseline (about 15 minutes before cold pressor task) and about 2 minutes after the start of the cold pressor task
Change in Stress Reactivity as Assessed by Heart Rate During the Cold Pressor Test (CPT)
Timeframe: Day 8 baseline (about 15 minutes before cold pressor task) and about 2 minutes after the start of the cold pressor task
Change in Stress Reactivity as Assessed by Cortisol During the Cold Pressor Test (CPT)
Timeframe: Day 1 baseline (about 15 minutes before cold pressor task) and about 30 minutes after the start of the cold pressor task, Day 8 baseline (about 15 minutes before cold pressor task) and about 30 minutes after the start of the cold pressor task
Smoking as Assessed by Latency to Self-Administration During the Smoking Relapse Assessment
Timeframe: Day 1
Smoking as Assessed by Number of Self-Administrated Cigarettes During the Smoking Relapse Assessment
Timeframe: Day 1
Change in Sleep Quality as Assessed by the Garmin Vivosmart3 Actigraphy Device
Timeframe: Day 1, Day 8
Change in Sleep Duration as Assessed by the Garmin Vivosmart3 Actigraphy Device
Timeframe: Day 1, Day 8
Change in Sleep Restlessness as Assessed by the Garmin Vivosmart3 Actigraphy Device
Timeframe: Day 1, Day 8
Smoking as Assessed by Number of Self-Administrated Cigarettes During the Smoking Relapse Assessment
Timeframe: Day 8
Smoking as Assessed by Latency to Self-Administration During the Smoking Relapse Assessment
Timeframe: Day 8
Nicotine Craving as Assessed by the Questionnaire of Smoking Urgers (QSU-brief)
Timeframe: Day 1
Nicotine Craving as Assessed by the Questionnaire of Smoking Urgers (QSU-brief)
Timeframe: Day 8