Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics
United States50 participantsStarted 2020-01-01
Plain-language summary
High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who regularly exercise are protected from these effects.
Who can participate
Age range
21 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy individuals (age 21-45) who are either sedentary (1 or less days of exercise per week during past year) or habitually active (4 or more days of aerobic exercise per week for a minimum of 1 year)
Exclusion Criteria:
* Body mass index \<18 or \>35
* Systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90
* Blood donation within past 8 weeks,
* Glucose 6 phosphate dehydrogenase (G6PD) deficiency
* A history of cancer, diabetes, or any other chronic disease
* A history of any heart disease
* A history of hormone therapy
* Use of nicotine products
* Pregnancy
* Nursing mothers
* Participation in regular physical activity greater than 1 day/week- but less than 4 days/week
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial focuses on how too much sodium in the diet affects blood vessel stiffness and blood flow — given my own sodium intake and cardiovascular health, does my doctor think this kind of research is relevant to my situation?
2Since this trial has an 'unknown' recruitment status, can my doctor help me find out whether it's still actively enrolling or if there's a similar study I could look into instead?
3The trial is measuring something called 'reflected pulse wave amplitude' and 'arterial stiffness' — can my doctor explain what those measurements mean for my heart health and whether I currently have any signs of these problems?
4This study doesn't appear to be testing a drug but rather looking at how dietary sodium affects blood vessels — would my doctor recommend I make changes to my sodium intake now based on existing evidence, rather than waiting to participate in a study?
5Since this trial has no listed phase, meaning it may be more of an observational or early-stage study, what does my doctor think is currently known about the risks of high sodium on blood vessel function, and how confident are they in that evidence?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.