CompletedNot Applicable

Periodontal Regeneration Versus Tooth Extraction and Replacement Denture in Teeth With Periodontal Hopeless Prognosis

Hong Kong50 participantsStarted 1998-06-01

Plain-language summary

Periodontal regeneration can change tooth prognosis and represents an alternative to extraction in teeth compromised by severe intrabony defects. The aim of this study is to compare periodontal regeneration (PR) with tooth extraction and replacement (TER) in a population with attachment loss to or beyond the apex of the root in terms of professional, patient reported and economic outcomes.

Who can participate

Age range

18 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Good general health * Non-smokers or smokers with less than 20/day * Good oral hygiene (FMPS\<25%) * Good control of periodontitis (FMBS\<25%) * Good compliance with treatment * Presence of generalised stage III or IV periodontitis * Radiographic bone loss to the apex or beyond the apex of the root at at least one interdental aspect * Presence of severe clinical attachment level loss (\>10 mm) * Presence of clearly identifiable crest of bone in adjacent teeth * Lack of function due to hyper mobility * Vital or non-vital teeth Exclusion Criteria: * Medical contraindication to elective surgery * Poor oral hygiene * Incomplete control of periodontitis in the dentition * Inadequate compliance * Inability to provide informed consent

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Tooth or tooth replacement survival

Timeframe: 10 year

Occurrence and cost of management of recurrence

Timeframe: 10-year

Oral health related quality of life: OHIP-14 (Oral Health Impact Profile)

Timeframe: 10 years

Trial details

NCT IDNCT04227964

SponsorThe European Research Group on Periodontology (ERGOPerio)

Sponsor typeNETWORK

Study typeINTERVENTIONAL

Primary completion2014-12-31

View on ClinicalTrials.gov More Periodontitis Complex trials