Acetazolamide Add-On Therapy to OSA Surgery

Inclusion Criteria: * Diagnosis of moderate to severe OSA (i.e. 15≤ AHI \<65 events per hour) * Eligibility for either BRP or UAS surgery * Fitness for general anesthesia (ASA ≤2) * Capability of giving informed consent and willingness to undergo surgery Exclusion Criteria: * Craniofacial anomalies affecting the UA * Body mass index (BMI) \>35 kg/m² * General contra-indications for surgery * Central sleep apnea (defined as central AHI ≥5 events per hour) * Contra-indications related to acetazolamide treatment * Hypersensitivity to sulfonamides or acetazolamide * Renal impairment (eGFR \<60 ml/min/1.73m²), electrolyte imbalances (sodium levels \<135 mmol/L or potassium levels \<3.5 mmol/L) and/or adrenocortical insufficiency * Clinically significant neurological, metabolic (including diabetes mellitus type 1 or 2), hepatic (alanine transaminase or aspartate transaminase \>2 times the upper limit of normal) and/or hematological disease * Chronic obstructive pulmonary disease * Closed-angle glaucoma * Professional driving or handling complex machinery due to the potential risk of exaggerated daytime sleepiness * Concomitant intake of drugs that influence breathing, sleep, arousal and/or muscle physiology * Inability of the patient to understand and/or comply to the study procedures * Active psychiatric disease (psychotic illness, major depression, anxiety attacks, and alcohol or drug abuse) which prevents compliance with the requirements of the research setting *…