CompletedNot Applicable

Perioperative Residual Adrenal Function After Extended Resection for Retroperitoneal Soft Tissue Sarcomas

Italy52 participantsStarted 2019-06-01

Plain-language summary

Early recognition of adrenal function deficit in patients undergoing multivisceral surgery including adrenalectomy for primitive retroperitoneal sarcomas

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients (age\> 18 years) * Diagnosis of retroperitoneal sarcoma * Adrenalectomy enbloc included in multivisceral resection * Voluntary informed written consent Exclusion Criteria: * Recurrent and / or metastatic disease * Patient chronically treated with corticosteroids * Primary disorders of adrenal gland * Basal serum cortisol values ≤ 7 µg / dL * Clinically significant heart disease * Altered TSH

What they're measuring

Serum Cortisol peak after low dose Synachten stimulation test.

Timeframe: 1st postoperative day

Serum Cortisol peak after low dose Synachten stimulation test.

Timeframe: 10th postoperative day

Serum Cortisol peak after low dose Synachten stimulation test.

Timeframe: 4 months after surgery (only if test positive on 10th postoperative day)

Trial details

NCT IDNCT04225494

SponsorFondazione IRCCS Istituto Nazionale dei Tumori, Milano

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-08-31

View on ClinicalTrials.gov More Adrenal; Functional Disturbance trials