This pilot study experimentally manipulates ovarian hormones to examine the direct impact of estrogen (E2) and progesterone (P4) on binge eating symptom burden and the behavioral reward response in women with bulimia nervosa (n=15). This is completed by taking medications that change ovarian hormone levels. This line of research could lead to the development of pharmacological interventions developed to target specific areas of the brain, brain receptors, or pathways identified to be involved in the mechanism underlying ovarian hormone change and binge eating.
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Change in Binge Eating Sum Score
Timeframe: Baseline (Day 14 of baseline) to End of Intervention (Day 14 of each intervention)
Change in Weekly Average Binge-eating Frequency
Timeframe: Baseline (Day 14 of baseline) to End of Intervention (Day 14 of each intervention)
Change in Self-Reported Reward Sensitivity Subscale Score During Estradiol Manipulation
Timeframe: Baseline (Day 14 of baseline) to End of Intervention (Day 14 of intervention)
Change in Response Latency to Reward During the Monetary Incentive Delay Task During Estradiol Manipulation
Timeframe: Baseline (Day 14 of baseline) to End of Intervention (Day 14 of intervention)
Change in Delay Discounting Parameter k Using the Monetary Choice Questionnaire With Estradiol Manipulation
Timeframe: Baseline (Day 14 of baseline) to End of Intervention (Day 14 of intervention)
Change in Self-Reported Behavioral Inhibition Score During Estradiol Manipulation
Timeframe: Baseline (Day 14 of baseline) to End of Intervention (Day 14 of intervention)
Change in Behavioral Activation Score During Estradiol Manipulation
Timeframe: Baseline (Day 14 of baseline) to End of Intervention (Day 14 of intervention)
Change in Behavioral Activation Reward Responsiveness With Estradiol Manipulation
Timeframe: Baseline (Day 14 of baseline) to End of Intervention (Day 14 of intervention)
Change in Behavioral Inhibition During Estradiol Administration as Assessed Through a Behavioral Task
Timeframe: Baseline (Day 14 of baseline) to End of Intervention (Day 14 of intervention)
Correlation Between Change in Reward Response and Change in Binge Eating Before and During Estradiol Manipulation
Timeframe: Baseline (Day 14 of baseline) to End of Intervention (Day 14 of intervention)