Evaluation of Naloxegol in the Prevention of POI After Cystectomy

Inclusion Criteria: * Patients aged ≥ 18 years * Informed consent signed * Histopathological confirmation of bladder cancer * Patients undergoing radical cystectomy and urinary diversion for an oncological indication * Patients able to understand the study procedures, agreed to participate in the study program * Patients affiliated to the national "Social Security" regimen or beneficiary of this regimen Exclusion Criteria: * Unwilling to undergo cystectomy * Cystectomy for non-oncological indication * Patients with concomitant upper urinary tract disease * Previous total colectomy, gastrectomy, or gastric bypass, or functional colostomy or ileostomy * Previous pelvic radiotherapy for prostate or bladder cancer * Patients having taken opioids for more than seven days before surgery (to prevent peripheral withdrawal effects) * Patients treated with drugs metabolized by certain enzymes (CYP3A4 and P-gp) * Patients with severe hepatic impairment * Patients with end-stage renal disease * Patients with heart failure * Patients with severe dementia that impacts daily functioning * Pregnant and lactating females * Not postmenopausal females and of childbearing potential and not using an accepted method of birth control (i.e, surgical sterilization; intrauterine contraceptive device; oral contraceptive, diaphragm) * Patients participated in another investigational drug or medical device study within 30 days of surgery or planning to be enrolled in another investigational drug or me…