Ischemia-reperfusion (IR) injury during liver transplantation is one of the major causes of mortality and morbidity associated with transplantation. Remote organ ischemic preconditioning (RIPC) is one of the most investigated practices to reduce IR injury. In this study, for the first time in the clinic, the effect of RIPC will be evaluated via both systemic inflammation parameters and also parameters showing glycocalyx integrity, on living-donor liver recipients.
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Tumor necrosis factor-alpha (TNF-alpha)
Timeframe: Postoperative early period (6 hours after intensive care unite admission)
Intercellular adhesion molecule-1 (ICAM-1)
Timeframe: Postoperative early period (6 hours after intensive care unite admission)
Hypoxia-induced factor-1 (HIF-1)
Timeframe: Postoperative early period (6 hours after intensive care unite admission)
Interleukin-8 (IL-8)
Timeframe: Postoperative early period (6 hours after intensive care unite admission)
Syndecan-1 (SDC-1)
Timeframe: Postoperative early period (6 hours after intensive care unite admission)
soluble Vascular cell adhesion molecule-1 (sVCAM-1).
Timeframe: Postoperative early period (6 hours after intensive care unite admission)