An Exploratory Clinical Trial Evaluating the Tolerability and Efficacy of KH906 in Patients With … (NCT04215393) | Clinical Trial Compass
UnknownPhase 1
An Exploratory Clinical Trial Evaluating the Tolerability and Efficacy of KH906 in Patients With Corneal Neovascularization
China39 participantsStarted 2019-07-18
Plain-language summary
The first stage of this study will evaluates the tolerability of different concentrations of Conbercept eye drop to patients with corneal neovascularization.
The second stage of this study will evaluate the effectiveness of conbercept eye drop initially.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Signed the informed consent form, volunteered to participate in the trial and followed up according to the protocol.
* Ages from 18 to 75,male or female.
* Superficial or deep neovascularization induced by trauma/chemical burn/inflammation/corneal transplantation.
Exclusion Criteria:
* Subjects who had significant defect in the corneal epithelium.
* Study eye had been injected of anti-vegf drugs within 3 months before screening
* Study eye was performed surgery (except keratoplasty) within 3 months prior screening, or eye surgery was planned during this trial period.
* Oral glucocorticoid administration within 1 month prior screening (except for duration less than 7 days)
* Systemic use of anti-vegf drugs within 45 days prior to screening.
* Have history of abnormal coagulation, such as end-stage liver disease, or are taking anticoagulants(except aspirin).
* Uncontrolled clinical problems such as canner etc..
* Unable or unwilling to use effective contraception.
* Positive blood tests for pregnancy (female subjects)
* Participated in drug clinical trials within 3 months before the first administration.
* The researchers think the participants were not suitable for this trail.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Ocular and Systemic Safety: occurrence of ocular and systemic adverse events