Safety and Feasibility of Pulmonary Surgery Marker System in the Intraoperative Localization of Small Pulmonary Nodules

Inclusion Criteria: Subjects should meet all of the following criteria * diagnosis of pulmonary nodule, single nodule operation to be performed and nodule to be located by the decision of chief surgeon. * commit to follow the research procedures and cooperate with the implementation of the whole process research * 1 / 3 of pulmonary nodules are located in the periphery of the lung * signed informed consent with date Exclusion Criteria: * the target lesion is close to the hilar or large blood vessels * subjects with FEV1 less than 1.2 in lung function * subjects with cardiac function III and cardiac function IV (NYHA, New York) * subjects with uncontrollable acute pleura infection * patients with previous history of thoracic surgery (thoracotomy), plural infection, and plural thickening and adhesion on the affected side * Other factors that investigators disagree enrollment.