Neuroimmune Dysfunction in Alcohol Use Disorder

AUD Group Inclusion Criteria: * Meet DSM-5 diagnostic criteria for an AUD * In the 30-day period before enrollment, consume ≥ 14 and ≥ 7 standard drinks per week for men and women, respectively, AND * In the 30-day period before enrollment, engage in heavy drinking (5 or more drinks for men, 4 or more drinks for women) and ≥ 5 times per month AUD Group Exclusion Criteria: * Currently in treatment for AUD, a history of treatment within the 30 days before enrollment, or currently seeking immediate treatment * Current (last 12 months) DSM-5 diagnosis of substance use disorder for any psychoactive substances other than alcohol and nicotine * Currently prescribed a psychotropic medication for the treatment of schizophrenia spectrum and other psychotic disorders, bipolar and related disorders, depressive disorders, anxiety disorders, and mood disorders. * Lifetime DSM-5 diagnosis of schizophrenia spectrum and other psychotic disorders and bipolar and related disorders * Positive urine toxicology screen for the following substances: cocaine, opiates, amphetamines, methamphetamine, phencyclidine, barbiturates, benzodiazepine, methadone, and tricyclic antidepressants. * Self-reported daily use of cannabidiol (CBD) or opioids (including prescribed) * Serious alcohol withdrawal symptoms as indicated by a score ≥ 10 on the Clinical Institute Withdrawal Assessment for Alcohol-Revised * If female: pregnancy, nursing, or refusal to use reliable method of birth control; if using hormonal …