Models of Auditory Hallucination (NCT04210557) | Clinical Trial Compass
TerminatedNot Applicable
Models of Auditory Hallucination
Stopped: Unable to recruit enough suitable participants.
United States1 participantsStarted 2020-02-27
Plain-language summary
The purpose of this study is to address the shortcoming in clinical hallucination research by causally manipulating the neural loci of conditioned hallucination task behavior in-person in patients with psychosis using transcranial magnetic stimulation (TMS), tracking the impact of this manipulation on the number of times participants with hallucinations report hearing tones that were not presented. With such a causal intervention, the veracity of this explanation of hallucinations will be either validated or disconfirmed. If validated, the task can be further developed as a biomarker for predicting the hallucination onset, guiding, developing or tracking the effects of treatments for hallucinations.
Who can participate
Age range
18 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged 18 - 45 years
* Voice hearing patients
* Meet diagnostic criteria for DSM-V schizophrenia or schizophreniform disorder
* Report hearing voices at least once a day
* Score \> 3 on PANSS P3 (hallucinations item)
Exclusion Criteria:
* DSM-V substance use disorder within the past 6 months
* Previous head injury with neurological symptoms and/or unconsciousness
* Intellectual disability (IQ \< 70)
* Non-English speaker
* Contraindications for TMS, including:
* History of seizures
* Metallic implants
* Pacemaker
* Pregnancy
* Less than 6 weeks of a stable dose of psychotropic medication(s)
* Comorbid mood or anxiety diagnosis
* Clinically/behaviorally instability and unable to cooperate with TMS procedures
* Clinically significant medical condition(s)
* Unstable medical condition(s) based on EKG, medical history, physical examination, and routine lab work
* Personal history of stroke
* Family history of seizures
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.