Intensive Care Unit Acquired Delirium (ICU-AD) and Intensive Care Unit Acquired Weakness (ICU-AW) are common in critically ill, mechanically ventilated adult patients. As more patients survive ICU stays but suffer from long-term functional declines leading to unemployment and disability, research is urgently needed. The aims of this study are to: 1) describe the trajectory of physical functions one year after ICU discharge, including distance walked in 6 minutes (6MWD), hand grip (HGS), maximum inspiratory pressure (MIP), cognitive function (mini mental state examination,MMSE), physical function ICU test score (PFITs) , medical reserach council scale (MRC), medical research council questionnaire (MRC-Q)and basic and instrumental activities of daily living (ADL/IADL); 2) examine the incidences of ICU-AD and ICU-AW; and 3) test the interaction between ICU-AD and ICU-AW on one-year functional trajectories in the ICU survivors.4) compare two tools, the intensive care delirium screening checklist (ICDSC) and confusion assessment method for the ICU (CAM-ICU), for their predictive validity for outcomes related to delirium, hospital mortality and length of stay (LOS), and examined whether the tools' predictive validity was affected by patients' arousal status (RASS≥0, RASS\<0).
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Change from baseline 6-min walking distance to one year after ICU discharge
Timeframe: Baseline at ICU discharge one month. One,two, three,six month and one year after ICU discharge
Change from baseline hand grip strength to one year after ICU discharge
Timeframe: Baseline at ICU discharge. One, two, three,six month and one year after ICU discharge
Maximum inspiratory pressure, from baseline to one year after ICU discharge
Timeframe: Baseline at ICU discharge one month. Two, three, six month and one year after ICU discharge
Change from baseline Mini-Mental State Examination to one year after ICU discharge
Timeframe: Baseline at ICU discharge. One, two, three, six month and one year after ICU discharge
Physical function
Timeframe: Three months after ICU discharge
Activities of daily living score, from baseline to one year after ICU discharge
Timeframe: Baseline before hospital admission. ICU discharge, one, two, three,six month and one year after ICU discharge
Instrumental activities of daily living score, from baseline to one year after ICU discharge
Timeframe: Baseline at ICU discharge one month. Two, three, six month and one year after ICU discharge
Scores of Medical Research Council (MRC) scale, from baseline to one year after ICU discharge
Timeframe: Baseline at ICU discharge. One year after ICU discharge
Self-report MRC questionnaire score
Timeframe: At ICU discharge one month
Sit-to-stand ability (yes/no)
Timeframe: Three months after ICU discharge