CompletedNot Applicable

Aortic Valve Dynamics During Exercise After Valve Sparing Root Replacement Surgery

Belgium20 participantsStarted 2019-12-16

Plain-language summary

Aortic valve sparing operations are applied in patients with a non-calcified tricuspid or bicuspid aortic valve associated with a root aneurysm, in order to preserve the valve, and avoid new aortic dilatation by stabilizing the aortic valve anulus with a graft prosthesis. This results in a normal functioning aortic valve, with a low forward gradient across the left ventricular outflow tract. Little is known about how the repaired aortic valve behaves in conditions of controlled exercise, and how the gradients across the valve change during exercise.

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * been operated with a valve sparing root procedure in the University Hospital Ghent, Belgium, since 2000 * being able to perform an exercise test on a reclining bicycle * normal left ventricular function Exclusion Criteria: * \<18 years or \>60 years of age * peak gradient across the aortic valve at rest of \>20mmHg * decreased left ventricular function

What they're measuring

Echocardiographic gradients in mmHg and velocity across the aortic valve in m/sec at each exercise level

Timeframe: from 1 year postoperatively

comparison between peak gradients in mmHg across tricuspid and bicuspid aortic valves

Timeframe: from 1 year postoperatively

Trial details

NCT IDNCT04205474

SponsorUniversity Hospital, Ghent

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-09-10

View on ClinicalTrials.gov More Aneurysm Aortic Root trials