Assessment of Wearable Sensors During Experimental Human Influenza Infection (Sigma Plus)

Inclusion Criteria: * Healthy persons aged 18 to 55 years, able to give informed consent Exclusion Criteria: * Chronic respiratory disease (asthma, chronic obstructive pulmonary disease, rhinitis, sinusitis) in adulthood * Inhaled bronchodilator or steroid use within the last 12 months * Use of any medication or other product (prescription or over-the-counter) for symptoms of rhinitis or nasal congestion within the last 3 months * Acute upper respiratory infection (URI or sinusitis) in the past 6 weeks * Smoking in the past 6 months OR \>5 pack-year lifetime history * Subjects with allergic symptoms present at baseline * Clinically relevant abnormality on chest X-ray * Any ECG abnormality deemed clinically significant. * Those in close domestic contact (i.e. sharing a household with, caring for, or daily face to face contact) with children under 3 years, the elderly (\>65 years), immunosuppressed persons, or those with chronic respiratory disease * Subjects with known or suspected immune deficiency * Receipt of systemic glucocorticoids (in a dose ≥ 5 mg prednisone daily or equivalent) within one month, or any other cytotoxic or immunosuppressive drug within 6 months prior to challenge * Known immunoglobulin A deficiency, immotile cilia syndrome, or Kartagener's syndrome * History of frequent nose bleeds * Any significant medical condition or prescribed drug deemed by the study doctor to make the participant unsuitable for the study * Pregnant or breastfeeding women * Posit…